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. 2021 Jul 10;11:386. doi: 10.1038/s41398-021-01510-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Manhattan plot of the GWAS of lgTMT-B in the discovery sample. The lines in (A) and (B) indicate the thresholds for the genome-wide significance of 5 × 10⁻⁸ (red) and for suggestive SNPs (blue, P ≤ 1 × 10⁻⁵). B Manhattan plot of the GWAS of VDS-B in the discovery sample. C Mean profile of TMT-B by the top SNP rs150547358 genotypes for the discovery sample (1039 AA, 28 AC, 0 CC) with the 95% confidence intervals. D GWAS regional Manhattan plot of chromosome 5 for lgTMT-B of the discovery sample. Colors indicate the LD values (r²) of SNPs with rs150547358 (in purple).