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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Connect Tissue Res. 2021 Jan 11;63(1):3–15. doi: 10.1080/03008207.2020.1865938

Figure 2.

Figure 2.

(A) Averaged cortical profiles of male and female mice at the proximal-mid position show improvements due to loading and RAL. (B) Measures of the total cross-sectional area (Tt.Ar), (C) cortical area (Ct.Ar), and (D) cortical thickness (Ct.Th) were significantly impacted by both load and RAL in males, resulting in a graded response. In contrast, in females, while there was some effects of RAL, the robust increases were primarily driven by load. (E) Maximum moment of inertia (Imax) was impacted by loading in both sexes, while (F) minimum moment of inertia (Imin) was positively influenced by RAL as well as the loading. (G) Tissue mineral density (TMD) showed no response in males, while it was significantly increased with loading in females. For a two-way ANOVA, a ‘&’ indicates a main effect of RAL and an ‘*’ indicates a main effect of loading. If the interaction term was significant, an ‘a’ indicates a significant difference from non-loaded control, ‘b’ indicates a significant difference from loaded control, and ‘c’ indicates a significant difference from non-loaded RAL.