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. 2021 Jul 11;22:40. doi: 10.1186/s40360-021-00505-x

Table 4.

Mixed Effects Model Regressions

Parameters Model Parameters
Parameter Estimate (C.I.) P-Value SD AIC BIC logLik
lme(TestCa ~ Race)
  Asian-Am. − 0.2 (− 0.39, − 0.02) 0.0320 1.141 3566.977 3595.930 − 1777.489
  Hispanic-Am. 2.82 (2.65, 3) 2.5E-150
  NHCaucasian-Am. 4.17 (4, 4.34) 1.3E-246
lme(TestCa ~ Ethnic_THC_Exposure)
  Ethnic_THC_Exp 0.05 (0.04, 0.06) 4.40E-31 0.202 − 1595.682 −1570.036 801.841
lme(TestCa ~ Race + Ethnic_THC_Exposure)
  NHCaucasian-Am. 4.06 (3.88, 4.23) 1.13E-234 1.126 3546.406 3580.177 − 1766.203
  Hispanic-Am. 2.93 (2.76, 3.11) 4.23E-155
  Ethnic_THC_Exp 0.24 (0.15, 0.32) 2.13E-07
lme(TestCa ~ Race * Ethnic_THC_Exposure)
  NHCaucasian-Am. 4.12 (3.95, 4.3) 9.4E-236 1.115 3539.109 3587.320 − 1759.554
  Hispanic-Am. 3.17 (2.96, 3.37) 1.5E-141
  Hispanic-Am.: Ethnic_THC_Exp 0.58 (0.4, 0.77) 6.6E-10
  NHCaucasian-Am.: Ethnic_THC_Exp 0.16 (0.05, 0.27) 0.0044
  Asian-Am.: Ethnic_THC_Exp 0.15 (−0.12, 0.43) 0.2753
  Asian-Am. 0.06 (− 0.42, 0.54) 0.8075
  NHAfrican-Am.: Ethnic_THC_Exp −0.05 (− 0.35, 0.25) 0.7381
lme(TestCa ~ Year * Race)
  Year: Hispanic-Am. 0.2 (0.17, 0.22) 2.9E-38 1.036 3427.797 3476.008 − 1703.898
  Year: NHCaucasian-Am. 0.02 (0.01, 0.04) 0.0032
  Hispanic-Am. −396.69 (− 504.97, −288.41) 1.5E-12
lme(TestCa ~ Year * Ethnic_THC_Exposure)
  Ethnic_THC_Exp 1.39 (1.25, 1.53) 1.51E-72 2.110 4659.713 4683.846 − 2324.857
  Year −0.14 (−0.18, − 0.11) 2.21E-17
Additive Model
lme(Rate ~ Cigarettes + AUD + Ethnic_THC_Exp + Analgesics + Cocaine)
  AUD 5.49 (5.11, 5.87) 6.57E-162 0.180 − 2610.768 − 2559.484 1313.384
  Ethnic_THC_Exp 0.05 (0.04, 0.06) 5.80E-31
  Cocaine −2.46 (−3.3, −1.62) 1.17E-08
  Analgesics −0.13 (− 0.16, − 0.1) 3.09E-21
  Cigarettes − 1.12 (− 1.27, − 0.97) 7.42E-49
Interactive Model - 3-Way
lme(Rate ~ Cigarettes * AUD * Ethnic_THC_Exp + Analgesics + Cocaine)
  Cigarettes: AUD 23.11 (21.54, 24.67) 2.14E-169 0.179 − 2675.013 − 2617.321 1346.507
  Cigarettes: Ethnic_THC_Exp 0.44 (0.31, 0.57) 5.22E-11
  Ethnic_THC_Exp −0.05 (− 0.08, − 0.01) 3.80E-03
  Cocaine −1.96 (−2.8, − 1.11) 6.09E-06
  Analgesics − 0.13 (− 0.16, − 0.11) 2.56E-22
  Cigarettes − 2.4 (− 2.59, − 2.2) 2.39E-124
Interactive Model - 4-Way
lme(Rate ~ Cigarettes * AUD * Ethnic_THC_Exp * Analgesics + Cocaine)
  Cigarettes: AUD 23.48 (21.9, 25.05) 6.73E-172 0.177 − 2725.041 − 2648.125 1374.520
  Analgesics 0.31 (0.15, 0.48) 0.0002
  Ethnic_THC_Exp: Analgesics 0.22 (0.07, 0.37) 0.0036
  Ethnic_THC_Exp 0.64 (0.17, 1.1) 0.0072
  Cigarettes: Ethnic_THC_Exp −3.8 (−5.8, −1.79) 0.0002
  Cigarettes: Ethnic_THC_Exp: Analgesics −1.38 (−2.03, −0.73) 3.19E-05
  Cocaine −1.87 (−2.71, − 1.02) 1.62E-05
  Cigarettes: Analgesics −2.21 (− 2.96, − 1.47) 6.05E-09
  Cigarettes −9.3 (− 11.61, −6.99) 3.98E-15