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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Pain. 2020 Sep 1;161(9):2179–2190. doi: 10.1097/j.pain.0000000000001905

Figure 3.

Figure 3.

Effect of MRS5980 and linaclotide on visceral pain induced by DNBS in female rats. Effect of MRS5980 (0.3, 1.2, and 2.4 μmol·kg−1; i.p.) and linaclotide (0.2 nmol·kg−1 p.o.) on visceromotor response (VMR, A) to CRD on day 14 after DNBS injection. Effect of MRS5980 (0.3, 1.2, and 2.4 μmol·kg−1; i.p.) on abdominal withdrawal reflex (AWR, B) to CRD on day 14 after DNBS injection. Each value is the mean ± SEM of 6 rats per group. ^^P < 0.01 vs vehicle-treated normal controls (violet). *P < 0.05 and **P < 0.01 vs DNBS + vehicle-treated group (red). CRD, colorectal distension.