Table 5.
Change in FVC and FEV1 according to telomere length (COPD patients, n=285)
| Tertile 1* (<7.39) | Tertile 2* (7.39–20.58) | Tertile 3* (>20.58) | p trend | |
|---|---|---|---|---|
| Pre-bronchodilator | ||||
| FVC, mL/yr | −5.652±2.004 | −6.358±2.248 | −7.346±2.706 | <0.001 |
| FEV1, mL/yr | −3.297±2.005 | −5.225±2.197 | −4.206±2.477 | 0.679 |
| Post-bronchodilator | ||||
| FVC, mL/yr | −5.003±1.900 | −5.368±2.114 | −4.606±2.518 | 0.856 |
| FEV1, mL/yr | −2.463±0.975 | −2.958±1.078 | −1.998±1.269 | 0.674 |
Adjusted variables: sex, age, smoking status, height.
*
COPD patients were divided into three groups based on telomere length, with the first tertile being the shortest and the third tertile being the longest.
FVC: forced vital capacity; FEV1: forced expiratory volume in 1 second; COPD: chronic obstructive pulmonary disease.