Table 2.
Characteristics and radiological HRCT features of HP patients stratified into fibrotic and non-fibrotic groups according to HRCT
| Characteristic | Fibrotic HP (n=27/51) | Non-fibrotic HP (n=24/51) | p-value | ||
|---|---|---|---|---|---|
|
|
|
||||
| Mean±SD | Median | Mean±SD | Median | ||
| Age, yr | 40.56±10.51 | 39 | 39.04±12.99 | 35 | 0.648 |
|
| |||||
| BMI, kg/m2 | 31.81±7.13 | 30 | 27.29±5.34 | 28 | 0.014 |
|
| |||||
| Dyspnea score | 3.15±0.86 | 3 | 2.67±0.87 | 3 | 0.053 |
|
| |||||
| PaO2, mm Hg | 62.44±14.88 | 65 | 73.88±15.04 | 80 | 0.009 |
|
| |||||
| SaO2, % | 88.63±8.36 | 90 | 93.17±5.00 | 94 | 0.025 |
|
| |||||
| 6MWD, m | 279.07±120.54 | 280 | 322.92±119.45 | 333 | 0.060 |
|
| |||||
| Pre-6MWT SO2, % | 89.22±7.71 | 90 | 93.96±4.18 | 95 | 0.010 |
|
| |||||
| Post-6MWT SO2, % | 74.15±10.82 | 79 | 83.67±10.89 | 88 | 0.003 |
|
| |||||
| FVC (% of predicted) | 52.48±11.30 | 52 | 69.17±12.88 | 71 | <0.001 |
|
| |||||
| FEV1/FVC | 84.22±8.20 | 84 | 82.21±11.13 | 84 | 0.462 |
|
| |||||
| KL-6, IU/mL | 1,165.00±283.0 | 1,200 | 2,020.83±870.77 | 1,900 | 0.020 |
|
| |||||
| Duration of steroid therapy, mo | 26.48±42.33 | 12 | 16.17±27.33 | 3 | 0.184 |
|
| |||||
| Total dose of steroids, mg/day | 17.6±10.5 | 20 | 20.4±16.4 | 20 | 0.230 |
|
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| HRCT findings, n (%) | |||||
|
| |||||
| GGO | 26 (96.3) | 23 (95.8) | >0.990 | ||
|
| |||||
| Nodules | 12 (44.4) | 11 (45.8) | 0.921 | ||
|
| |||||
| Mosaic | 17 (63.0) | 12 (50) | 0.351 | ||
|
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| Linear reticulations | 27 (100) | 0 | <0.001 | ||
|
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| Traction bronchiectasis | 21 (77.8) | 0 | <0.001 | ||
|
| |||||
| Honeycombing | 3 (11.1) | 0 | <0.001 | ||
p<0.001 is considered highly significant; p<0.05 is considered significant.
HRCT: high-resolution computed tomography; HP: hypersensitivity pneumonitis; SD: standard deviation; BMI: body mass index; PaO2 (mm Hg): partial pressure of arterial oxygen; SaO2 (%): saturation of arterial oxygen; 6MWD: 6-minute walk distance; 6MWT: 6-minute walk test; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 second; KL-6: Krebs von Lungen-6; GGO: ground-glass opacities.