Table 2.
Tooth disturbances in the children and adolescents with osteogenesis imperfecta (OI) who had received bisphosphonate treatment (n = 55 total among the three groups)
| Patient | OI type | Age at imaging (years) |
Age at last clinical evaluation (years) |
DGIa | Congenitally missing teeth (tooth number) |
DI (tooth number) |
DE (tooth number) |
Anomalies in tooth size and form (tooth number) |
Enamel defectsb (tooth number) |
|---|---|---|---|---|---|---|---|---|---|
| Group 1: BP therapy onset before 2 years of age | |||||||||
| 1 | 1 | 14.7 | 18 | 0 | 15 | 35 | 14,24 | 25,45, | |
| 2 | 1 | 13.3 | 13.3 | 0 | 0 | 15,14,24,25,45,44,34,35 | |||
| 3 | 1 | 10.6 | 10.6 | 0 | 0 | 35,45,25 | |||
| 4 | 3 | 13.3 | 11.8 | 0 | 14,15,25,35,44,45 | 34 | |||
| 5 | 3 | 12.3 | 16.0 | 1 | 14,34 | 15 | 24,25,44,35 | 45 | |
| 6 | 3 | 9.5 | 7.1 | 1 | 0 | 45 | 35 | ||
| 7 | 3 | 9.7 | 9.7 | 1 | 15,14,24,25,35,45 | 34,44 | |||
| 8 | 3 | 7.3 | 7.5 | 1 | 15,24,25,35,45 | 34 | |||
| 9 | 3 | 12.3 | 12.3 | 0 | 14,15,24,25,35,34 | 45 | |||
| 10 | 3 | 11.5 | 11.5 | 1 | 15,14,24,25,45,35 | 34,44 | |||
| 11 | 3 | 10.0 | 15.00 | 1 | 15,24,25,44 | 35 | 14,34,45 | ||
| 12 | 3 | 10.5 | 10.5 | 1 | 14,15,25,34 | 35 | 45 | ||
| 13 | 3 | 13.8 | 13.8 | 0 | 0 | 15 | 35,45,14,24,44, | 45,34 | |
| 14 | 3 | 9.0 | 14.0 | 1 | 15,14,24,25,35,34,44,45 | ||||
| 15 | 3 | 5.7 | 5.7 | 0 | 0 | Evaluation not possible | |||
| 16 | 3 | 6.4 | 6.4 | 1 | 0 | Evaluation not possible | |||
| 17 | 4 | 11.2 | 11.2 | 1 | 15,25 | ||||
| 18 | 4 | 7.9 | 11.0 | 0 | 15,14,24,25,35,34,44,45 | ||||
| 19 | 4 | 9.1 | 16.5 | 1 | 0 | 45,35 | |||
| 20 | 4 | 7.7 | 7.7 | 0 | 15,14,13,24,25 | 45,35 | |||
| 21 | 4 | 10.0 | 10.0 | 1 | 0 | 44 | 35,45 | ||
| 22 | 4 | 8.7 | 12.9 | 0 | 0 | 45 | |||
| Group 2: BP therapy onset between 2 and 6 years of age | |||||||||
| 1 | 1 | 6.6 | – | 1 | 0 | ||||
| 2 | 1 | 6.0 | 8.9 | 0 | 0 | ||||
| 3 | 1 | 11.7 | 14.6 | 0 | 0 | ||||
| 4 | 1 | 10 | – | 0 | 0 | ||||
| 5 | 1 | 11.9 | 18.1 | 0 | 0 | ||||
| 6 | 1 | 9.9 | 12.9 | 0 | 0 | ||||
| 7 | 1 | 7.3 | 17.8 | 0 | 0 | ||||
| 8 | 1 | 6.1 | – | 0 | 0 | ||||
| 9 | 1 | 8.2 | 17.5 | 0 | 0 | ||||
| 10 | 1 | 6.2 | – | 0 | 0 | ||||
| 11 | 1 | 6.1 | 8.0 | 0 | 0 | ||||
| 12 | 3 | 9.2 | 17.9 | 0 | 0 | ||||
| 13 | 3 | 8.1 | – | 1 | 25 | ||||
| 14 | 3 | 7.0 | – | 0 | 0 | ||||
| 15 | 3 | 11 | 18.3 | 0 | 42,32 | ||||
| 16 | 3 | 9.9 | 9.9 | 0 | 0 | ||||
| 17 | 4 | 9.7 | – | 0 | 0 | ||||
| 18 | 4 | 8.9 | 8.9 | 1 | 0 | ||||
| 19 | 4 | 10.7 | 11.7 | 0 | 0 | ||||
| 20 | 4 | 10.8 | 7.3 | 0 | 0 | ||||
| Group 3: BP therapy onset between 6 and 10 years of age | |||||||||
| 1 | 1 | 11 | 11.5 | 0 | 0 | ||||
| 2 | 1 | 10.9 | 12.8 | 0 | 0 | ||||
| 3 | 1 | 10.3 | 8.4 | 0 | 0 | ||||
| 4 | 1 | 15 | 8.7 | 1 | 0 | ||||
| 5 | 1 | 9 | 10.0 | 1 | 0 | ||||
| 6 | 1 | 11.6 | – | 0 | 0 | ||||
| 7 | 1 | 9.2 | 14.7 | 0 | 0 | ||||
| 8 | 1 | 14.5 | 12.0 | 0 | 0 | ||||
| 9 | 3 | 11.4 | 11.4 | 0 | 0 | ||||
| 10 | 4 | 8.7 | 13.1 | 0 | 0 | ||||
| 11 | 4 | 7.6 | 7.6 | 0 | 15, 45 | ||||
| 12 | 4 | 11.6 | 15.5 | 0 | 0 | ||||
| 13 | 4 | 10.8 | 16.7 | 1 | 0 | ||||
a0 = no, 1 = yes
bhypoplasia/hypomineralization
OI type I mild OI with blue sclerae, OI type III severe deforming, OI type IV intermediate severity, and white sclerae after infancy, DGI dentinogenesis imperfect, DI Dens invaginatus, DE Dens evaginatus
Tooth numbers: 15 = right, second upper premolar; 14 = right, first upper premolar; 24 = left, first upper premolar; 25 = left, second upper premolar; 35 = left, second lower premolar; 34 = left, first lower premolar; 32 = left, second lower, incisor; 42 = right, second lower, incisor; 44 = right, first lower premolar; 45 = right, second lower premolar