Table 2. Aminoguanidine Methyl, Methoxy, Fluoromethyl, Fluoromethoxy, and Nitrile Series^a.

compound	R1	R2	IC50 D6 (nM)	IC50 Dd2 (nM)	IC50 Tm90–C2B (nM)	IC50 A6 (nM)	IC50 cytotoxicity (μM)	IVTI
10	4-CH3	H	905	2427	2529	>5000	43	48
11	4-OCH3	H	263	1602	>5000	289	>200	>100
12	4-CF3	H	614	1536	2742	567	40	65
13	4-CF3	CH3	211	414	451	283	114	>100
14	2-OCF3	H	1080	2328	>5000	391	156	>100
15	3-OCF3	H	670	1571	2988	689	61	91
16	4-OCF3	H	39	83	114	52	11	>100
17	4-OCF3	CH3	140	526	458	182	9	64
18	4-OCHF2	H	71	191	193	87	19	>100
19	4-OCHF2	CH3	99	403	315	171	3	30
20	2-CN	H	1024	2097	1990	969	31	30
21	3-CN	H	7	20	31	24	7	>100
22	4-CN	H	58	166	312	76	>200	>100
23	3-CN	CH3	47	70	104	17	9	>100
1	3-CN, 4-F	H	4	12	16	14	8	>100

^aSee Table 1 legend and Methods.