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| compound | P. yoelii ED50 (mg/kg/day) | P. yoelii ED90 (mg/kg/day) | P. yoelii NRD (mg/kg/day) |
|---|---|---|---|
| robenidine | 1.6 | 4.9 | >25 |
| 16 | 1.2 | 3.7 | 12.5 |
| 22 | 2.7 | 7.7 | >25 |
| 21 | 7.1 | 9.4 | >25 |
| 1 | 0.25 | 0.28 | >25 |
In vivo activity values were determined from a modified 4-day Peters test. Compounds were administered by oral gavage up to 25 mg/kg/day, near the solubility limit of the PEG delivery vehicle. NRD = nonrecrudescence dose (cure dose).
