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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Adv Healthc Mater. 2021 Jun 2;10(13):e2002196. doi: 10.1002/adhm.202002196

Figure 2.

Figure 2.

Nanoparticle aggregates (NPAs) dissociate at high shear stenosis sites to deliver antithrombotic drugs. (A) NPAs flow through a blood vessel under healthy, physiological shear flow conditions after intravenous injection. (B) At the thrombus site, the blood vessel narrows, producing a stenotic site and increasing local shear stress. This high shear stress region induces NP disaggregation, such that individual NP coated with tissue plasminogen activator (r-tPA) can amass around thrombus and dissolve it. Modified from [14].