Table 1.

A summary of major deformable-nanoparticle-based shear-sensitive drug delivery systems.

Drug carrier	Spherical liposome	Lenticular liposome	Nanogel	Micellar composite hydrogel
Payload	Eptifibatide[39]	Carboxyfluorescein for imaging[31]	Plasmalemma vesicle associated protein (PLVAP) antibody[58]	Simvastatin[71]
Drug target	Thrombosis	Constricted arteries with atherosclerosis	PLVAP in lung cells	Inflammatory macrophages at the thrombotic site
Drug development phase	Prevention of thrombotic occlusion in mice	Delivery of an imaging dye in an in vitro arterial model	Delivery of an antibody in mice	Inhibition of thrombosis in mice and rabbits
Carrier materials	Phosphatidylcholine with Brij 76	1,3-dipalmitamidopropan-2-yl 2-(trimethylammonio)ethyl phosphate (Pad–PC–Pad)	Lysozyme-dextran	Hyaluronic acid (HA) modified with glycidyl methacrylate
Carrier size	200 nm	100 nm	150–300 nm	Micelles: 100 nm
Shear range of release	> 1500 s−1	~40 Pa (2 Pa represents a healthy artery)	> 15 s−1	55% and 75% narrow flow states