Table 1.

Subject demographics and hematologic markers. Bold lettering denotes statistically significant p-values (p < 0.05).

	CTL (N = 44)	ACTL (N = 27)	SCD (N = 47)	p-value (ACTL–CTL)	p-value (SCD–CTL)	p-value (SCD–ACTL)
Age (Years)	26.4±10.6	25.0±10.4	21.1±7.1	0.81	0.07	0.39
Sex	14M, 30F	13M, 14F	26M, 21F	0.37	0.06	0.82
Body Mass Index	25.7±7.0	23.1±2.5	22.3±4.4	0.11	<0.01	0.79
Transfused	0/44	16/27	16/47	<0.01	<0.01	0.02
Arterial Saturation (%)	99±1	99±1	98±2	0.23	<0.01	0.01
Systolic Blood Pressure (mmHg)	118±13	113±9	112±11	0.16	0.04	0.97
Diastolic Blood Pressure (mmHg)	68±10	62±7	60±7	<0.01	<0.01	0.55
Mean Blood Pressure (mmHg)	85±13	80±7	78±9	0.09	<0.01	0.83
Hemoglobin Electrophoresis	21AA, 23AS	23AA, 3AE, 1AS	39SS, 6SC, 1Sβ0, 1Sβ+
Hemoglobin (g/dL)	13.5±1.2	10.6±2.6	9.7±1.8	<0.01	<0.01	<0.01
Hematocrit (%)	40.0±3.2	32.5±6.2	27.6±4.7	<0.01	<0.01	0.07
White Blood Cell Count (x103)	5.7±1.8	6.9±2.3	9.7±4.3	0.26	<0.01	<0.01
Platelet Count (x103/µL)	251±56	268±118	321±128	0.79	<0.01	0.09
Reticulocytes (%)	1.3±0.5	2.6±2.8	9.2±5.0	0.30	<0.01	<0.01
HbS (%)	20±19	0	55±29	<0.01	<0.01	<0.01
Fetal Hemoglobin (%)	0.4±1.8	2.2±4.0	8.4±8.7	0.46	<0.01	<0.01
Cell-free Hemoglobin (mg/dL)	6.3±5.3	16.9±18.0	21.3±20.0	0.02	<0.01	0.49
Red Blood Cell Distribution Width	13.6±1.7	17.9±5.4	18.6±3.8	0.01	<0.01	0.76
Silent Cerebral Infarct Presence	9/44	8/27	20/47	0.63	0.04	0.25
CBF (mL/100g/min)	61.8±9.8	83.0±16.4	97.8±24.9	<0.01	<0.01	0.01
O2 Content (mL O2/mL blood)	18.2±1.5	14.4±3.4	13.0±2.4	<0.01	<0.01	0.05
O2 Delivery (mL/100g/min)	11.2±1.9	11.5±1.9	12.3±2.3	0.75	0.07	0.44
OEF (%)	36.1±5.8	30.9±5.6	27.5±4.1	<0.01	<0.01	0.03
CMRO2 (mL O2/100g/min)	4.01±0.63	3.53±0.65	3.39±0.71	0.01	<0.01	0.22