Table 3. Estimates of functional status (Karnofsky Performance Status, KPS) levels at admission and postkidney transplantation (KT) trajectories among KT recipients in the Scientific Registry of Transplant Recipients between February 1990 and June 2019 (n= 224,832) by age, sex, race, and diabetes.
The Karnofsky Performance Status (KPS) score ranges from 0% to 100%. All models were adjusted for age, sex, race, cause of ESKD, years on dialysis, donor type, and diabetes status. Interaction models represent separate models for each respective factor. Bolded estimates represent statistically significant associations.
| Models | Level | Slope | ||
|---|---|---|---|---|
| KPS Score (%) at KT (95%CI) | p-value | KPS Score (%)/Year (95%CI) | p-value | |
| Overall | 88.4 (87.7, 89.0) | <0.001 | 0.89 (0.87, 0.91) | <0.001 |
| Interaction Models | Difference (95%CI) | p-value | Difference (95%CI) | pinteraction |
| Age (≥65 vs. <65) | −1.4 (−1.5, −1.3) | <0.001 | −0.49 (−0.53, −0.44) | <0.001 |
| Sex (female vs. male) | −0.4 (−0.5, −0.4) | <0.001 | 0.08 (0.04, 0.11) | <0.001 |
| Race (Black vs. non-Black) | 0.1 (0.01, 0.2) | 0.03 | −0.13 (−0.17, −0.09) | <0.001 |
| Diabetes (diabetes vs. no diabetes) | −5.1 (−5.2, −5.0) | <0.001 | 2.01 (1.95, 2.06) | <0.001 |
| Donor type (living vs. deceased) | 2.84 (2.74, 2.95) | <0.001 | −0.28 (−0.32, −0.24) | <0.001 |
| Delayed graft function (yes vs. no) | −2.16 (−2.28, −2.04) | <0.001 | 0.26 (0.21, 0.31) | <0.001 |
| Acute rejection (yes vs. no) | −1.16 (−1.48, −0.84) | <0.001 | −0.18 (−0.30, −0.05) | 0.005 |