Table 4. Associations with post-KT mortality and all cause graft loss among adult KT recipients (February 1990-June 2019) by functional status (KPS) at time of admission and change in functional status post-KT (n=224,832).
The Karnofsky Performance Status (KPS) ranges from 0% to 100%. Change in KPS refers to time-varying post-KT KPS. Results reflect the hazard ratios for every 10% reduction in KPS. All models were adjusted for age, sex, race, cause of ESKD, years on dialysis, and diabetes status. Older age interactions compared recipients ≥65 vs. <65 years. Subgroup hazard ratios are presented for models with interactions, which were performed separately for each respective factor. Bolded estimates represent statistically significant associations.
| KPS at Admission | Change in KPS | |||||
|---|---|---|---|---|---|---|
| Models | HR (95% CI) | P>z | HR (95% CI) | P>z | ||
| Mortality | ||||||
| Overall | 1.11 (1.10, 1.11) | <0.001 | 1.93 (1.92, 1.94) | <0.001 | ||
| Interaction Models | Yes | No | pinteraction | Yes | No | pinteraction |
| Older Age | 1.12 (1.10, 1.13) | 1.10 (1.09, 1.11) | 0.045 | 1.84 (1.83, 1.86) | 2.01 (2.00, 2.03) | <0.001 |
| Female Sex | 1.10 (1.09, 1.11) | 1.11 (1.10, 1.11) | 0.59 | 1.98 (1.96, 2.00) | 1.91 (1.89, 1.92) | <0.001 |
| Black Race | 1.12 (1.10, 1.13) | 1.10 (1.09, 1.11) | 0.05 | 1.93 (1.90, 1.95) | 1.94 (1.92, 1.95) | 0.51 |
| Diabetes | 1.10 (1.09, 1.11) | 1.11 (1.10, 1.12) | 0.05 | 1.95 (1.91, 1.99) | 1.93 (1.92, 1.94) | 0.42 |
| Death with Functioning Graft | ||||||
| Overall | 1.08 (1.07, 1.09) | <0.001 | 2.18 (2.15, 2.22) | <0.001 | ||
| Interaction Models | Yes | No | pinteraction | Yes | No | pinteraction |
| Older Age | 1.11 (1.09, 1.14) | 1.07 (1.06, 1.09) | 0.009 | 2.09 (2.04, 2.15) | 2.23 (2.19, 2.28) | <0.001 |
| Female Sex | 1.08 (1.06, 1.10) | 1.08 (1.07, 1.10) | 0.66 | 2.23 (2.17, 2.28) | 2.16 (2.12, 2.20) | 0.05 |
| Black Race | 1.07 (1.05, 1.09) | 1.08 (1.07, 1.10) | 0.30 | 2.14 (2.08, 2.21) | 2.20 (2.16, 2.24) | 0.16 |
| Diabetes | 1.08 (1.06, 1.09) | 1.08 (1.06, 1.10) | 0.63 | 2.13 (2.03, 2.24) | 2.19 (2.15, 2.23) | 0.31 |
| All-cause graft loss | ||||||
| Overall | 1.08 (1.08, 1.09) | <0.001 | 1.84 (1.83, 1.85) | <0.001 | ||
| Interaction Models | Yes | No | pinteraction | |||
| Older Age | 1.11 (1.09, 1.12) | 1.08 (1.07, 1.08) | <0.001 | 1.81 (1.79, 1.83) | 1.86 (1.84, 1.87) | <0.001 |
| Female Sex | 1.07 (1.07, 1.08) | 1.09 (1.08, 1.09) | 0.04 | 1.86 (1.84, 1.88) | 1.83 (1.82, 1.85) | 0.01 |
| Black Race | 1.08 (1.07, 1.09) | 1.08 (1.08, 1.09) | 0.84 | 1.78 (1.76, 1.80) | 1.87 (1.85, 1.88) | <0.001 |
| Diabetes | 1.09 (1.08, 1.09) | 1.08 (1.07, 1.09) | 0.35 | 1.89 (1.85, 1.93) | 1.84 (1.83, 1.85) | 0.03 |
Abbreviations: HR=hazard ratio; CI=confidence interval.