Table 3.

Multivariable time-dependent and independent regression models for death and/or heart transplantation.

	Baseline only		Time-varying only		Time-varying + baseline
Variable	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Gender = Male	1.71 (1.20–2.43)	0.003	–		1.40 (0.97–2.02)	0.071
Fontan type = ECC vs AP (reference)	0.36 (0.22–0.58)	<0.001	–		0.31 (0.19–0.51)	<0.001
Fontan type = LT vs AP (reference)	0.51 (0.32–0.81)	0.004	–		0.50 (0.31–0.80)	0.004
Age at Fontan (per year increase)	1.054 (1.024–1.086)	<0.001	–		1.028 (0.995–1.063)	0.098
Pre-Fontan Atrioventricular valve repair	4.37 (2.17–8.79)	<0.001	–		4.22 (2.09–8.51)	<0.001
Prolonged pleural effusions post Fontan	2.68 (1.51–4.79)	<0.001			2.45 (1.41–4.26)	0.002
Arrhythmia (Flutter, SVT or Fibrillation)*	–		2.82 (1.70–4.67)	<0.001	2.04 (1.20–3.46)	0.009
PLE/plastic bronchitis	–		3.66 (2.12–6.32)	<0.001	3.81 (2.19–6.62)	<0.001
Ventricular dysfunction	–		13.6 (9.08–20.3)	<0.001	13.9 (9.20–21.1)	<0.001
c-index	0.733		0.748		0.843