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. 2021 Jun 28;12:694510. doi: 10.3389/fphar.2021.694510

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Copyright © 2021 Gasparyan, Navarrete and Manzanares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of the basal behavioral disturbances induced by the animal model of PTSD at weeks 6 and 7. Analysis of the freezing time (s) by the fear conditioning (FC) paradigm (A), the startle amplitude (B) by the acoustic startle response (ASR), and of the latency time (C) and food pellets consumption (D) by the novelty suppressed feeding test (NSFT). Columns represent the mean and vertical lines ± SEM. *, Values from PTSD-like mice that are significantly different from control mice (Student’s t-test, p < 0.001). Mice exposed to the PTSD-like model: N = 8; control mice: N = 8.