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. 2021 Jun 28;12:694510. doi: 10.3389/fphar.2021.694510

FIGURE 5.

FIGURE 5

Evaluation of fear-related memory at weeks 11 and 14. Analysis of the freezing time (s) by the fear conditioning paradigm between control and PTSD-like VEH-treated mice at week 11 (A) and week 14 (D). Effects of acute (week 11) and chronic (week 14) administration of CBD (20 mg/kg, i.p.) and/or STR (10 mg/kg, p.o.), or its corresponding VEH, on the freezing time (s) of control mice (B, E) and PTSD-like mice (C,F). Columns represent the means and vertical lines ± SEM. *, Values from PTSD-like VEH-treated mice that are significantly different from control VEH-treated mice (Student’s t-test, p < 0.001). #, Values from CBD- or STR-treated groups that are significantly different from VEH-treated mice (Two-way ANOVA, p < 0.05). and, Values from CBD plus STR-treated mice that significantly different from CBD- and STR-treated control (Two-way ANOVA, p < 0.05) and PTSD-like mice (Two-way ANOVA, p < 0.001). Mice exposed to the PTSD-like model: N(VEH) = 10, N(CBD) = 10, N(STR) = 9, N(CBD plus STR) = 10; control mice: N(VEH) = 10, N(CBD) = 9, N(STR) = 9, N(CBD plus STR) = 10.