FIGURE 1.

Dietary intake of NR as pellet diet to mitigate C26 adenocarcinoma–induced cancer cachexia. (A) Schematic protocol for experiment Balb/c mice were administered with 1 × 10⁷ cells/ml on side of abdomen. Right picture shows representational tumors according to the groups. Tumor growth did not differ according to the groups. (B) Daily measurement of body weight according to the groups. Body weights after 2 weeks were significantly decreased in Group 2 compared to Group 3 and Group 4. (C) Representational gross morphology of thigh including gastrocnemius muscle. Significant atrophy was noted in Group 2 (p < 0.01). Using imaging analysis, individual muscle mass of leg was measured and averaged according to the groups. The mean size and volume of resected C26 adenocarcinoma xenograft after 3 weeks. (D) Mean tumor volume and tumor masses according to the groups. Though different in body weights and general condition, NR administration did not affect either tumor volume or tumor masses. Though omitted, the mean amounts of daily food intake were not differed according to the groups, suggesting that changes in either appetite or food consumption was not differed according to the groups.