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. 2021 Jun 28;15:667614. doi: 10.3389/fnins.2021.667614

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Copyright © 2021 Ando, Nobukawa, Kikuchi and Takahashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multi-scale entropy analysis in HC and AD group. The horizontal axis represents the temporal-scale factor, τ . (A) Mean values of sample entropy from 1 (0.005 s) to 30 (0.15 s) scale factors in HC (left part) and AD (right part). (B) t-value between the AD and HC groups(left part). The warm (cold) color represents a higher (smaller) sample entropy value for AD than that for HC. The t-value satisfying the FDR correction criteria q < 0.050 corresponding to (p < 0.002). Significantly smaller sample entropy of AD low temporal scale regions 1 to 5 (0.005 to 0.025 s).