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. 2021 Jun 28;14:678267. doi: 10.3389/fnmol.2021.678267

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Copyright © 2021 Beecher, Wang, Jacques, Chaaya, Chehrehasa, Belmer and Bartlett.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sucrose alters serotonin innervation in the PFC and DG of the hippocampus. A high-resolution representative image of the PFC (A) and DG of the hippocampus (E) showing the distribution of the reconstructed 5-HT, VGLUT3, and 5-HT/VGLUT3 co-localisation surfaces between water and sucrose consuming animals (Scale: 50 μm). Sucrose drinking does not alter the density of 5-HT varicosities (B) however, decreases the density of VGLUT3 varicosities (C) and the density of 5-HT/VGLUT3 co-localised varicosities (D) in the PFC. Sucrose drinking selectively decreases the density of varicosities of 5-HT (F), density of VGLUT3 varicosities (G) and density of 5-HT/VGLUT3 (H) co-localised varicosities in the DG of the hippocampus. Data are presented as mean ± S.E.M (t-test); n = 8 mice/group. *p < 0.05, ****p < 0.0001. PFC, prefrontal cortex; DG, dentate gyrus.