TABLE 3.

DNA methylation in vascular aging-related hypertension.

Genes	Methylation Status	Functions	References
sACE, ACE-1	Hyper	RAAS	Rivière et al., 2011
ACE-2	Hyper	RAAS	Fan et al., 2017
Atgr1α	Hypo	RAAS	Pei et al., 2015
Atgr1β	Hypo	RAAS	Bogdarina et al., 2007
AGT	Hypo	RAAS	Wang et al., 2014
AGTR1	Hypo	RAAS	Fan et al., 2015
SULF1, PRCP	Hyper	Inflammation	Wang et al., 2013
IL-6	Hypo	Inflammation	Mao S. Q. et al., 2017
IFN-γ	Hypo	Inflammation	Bao et al., 2018
TLR2	Hypo	Chronic inflammation	Mao S. et al., 2017
EHMT2	Hypo	Chronic inflammation	Boström et al., 2016
ADD1	Hypo	Ionic balance	Zhang et al., 2013
NKCC1	Hypo	Ionic balance	Cho et al., 2011
SCNN1B	Hyper/hypo	Ionic balance	Zhong et al., 2016
MTHFD1	Hyper	Hyperhomocysteinemia	Xu M. et al., 2019
CBS	Hyper	Hyperhomocysteinemia	Wang et al., 2019
SHMT1	Hyper	Hyperhomocysteinemia	Xu G. et al., 2019
ERα	Hyper	Vasodilation	Dasgupta et al., 2012
11βHSD2(HSD11B2)	Hyper	Aldosterone	Alikhani-Koopaei et al., 2004

RAAS, renin–angiotensin–aldosterone system.