TABLE 5.

DNA methylation-based drugs for vascular aging-related diseases.

Compounds	Nutrients/drugs	Functions	References
Natural	Folic acid	S-adenyl methionine generation	Park et al., 2012
	vitamins B6 and B12	S-adenyl methionine generation	Park et al., 2012
	Vitamin C	TET2 activator	DiTroia et al., 2019
	Methionine	Increase DNA methylation	Waterland, 2006
	Catechin, epicatechin	DNMTs inhibitor	Nagai et al., 2004
	EGCG	DNMTs inhibitor	Wong et al., 2011
	Resveratrol	DNMTs inhibitor	Aldawsari et al., 2016
	Quercetin	DNMTs inhibitor	Liu C. M. et al., 2015
Synthetic	Azacytidine	DNMTs inhibitor	Strand et al., 2020
	Decitabine	DNMTs inhibitor	Zhuang et al., 2017
	RG108	DNMTs inhibitor	Stenzig et al., 2018
	Hydralazine	DNMTs inhibitor	Kao et al., 2011
	GLP-1 agonists	DNMTs inhibitor and TET2 activator	Scisciola et al., 2020
	SGLT2 inhibitors	Not available	Marumo et al., 2015

EGCG, epigallocatechin-3-O-gallate; decitabine, 5-Aza-2′-deoxycytidine; TET, 10–11 translocations; DNMT, DNA methyltransferases.