Table 1.
Demographics at baseline.
| Population characteristics | Overall cohort | gBRCA-wt | gBRCA-mut |
|---|---|---|---|
| 35 (100.0%) | N=27 (77.1%) | N=8 (22.9%) | |
| Age (years) | |||
| Mean (SD) | 60 ( ± 15) | 62 ( ± 15) | 54 ( ± 12) |
| Germline BRCA1/2 Mutational Status | |||
| BRCA-mutant | 8 (22.9%) | 0 (0.0%) | 8 (100%) |
| BRCA-wild type | 27 (77.1%) | 27 (100.0%) | 0 (0.0%) |
| Breast Cancer Subtype | |||
| TNBC | 33 (94.3%) | 27 (100.0%) | 6 (75.0%) |
| HR+/HER2-neg. | 2 (5.7%) | 0 (0.0%) | 2 (25.0%) |
| HER2+ | 0 (0%) | 0 (0.0%) | 0 (0.0%) |
| Primary Tumor Dimension (mm) | |||
| Median (min - max) | 39 (18 - 80) | 37 (18 -75) | 50 (20 - 80) |
| TNM Stage | |||
| I-IIA | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| IIB-IIIC | 35 (100.0%) | 27 (100.0%) | 8 (100.0%) |
| IV | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| SUVmax | |||
| Median (min - max) | 9.3 (1.9 - 31.0) | 8.7 (1.9 - 31.9) | 11.7 (3.8 - 21.9) |
| Ki67% | |||
| Median (min - max) | 50% (10% - 90%) | 50% (15% – 90%) | 63% (10% - 80%) |
| TILs | |||
| Median (min - max) | 40 (10 - 90) | 40 (10 - 90) | 90 (10 - 90) |
| PD-L1 | |||
| Negative (<1%) | 9 (29.0%) | 8 (33.3%) | 1 (14.3%) |
| Positive (≥1%) | 22 (71.0%) | 16 (66.7%) | 6 (85.7%) |
Means with standard deviation are reported when the variable distribution was normal according to a Shapiro-Wilk test for normality, otherwise median values with minimum-maximum range are reported; SD, standard deviation; TILs, tumor-infiltrating lymphocytes; SUV, standard uptake volume; PD-L1, PD-L1 in tumor-infiltrating inflammatory cells; gBRCA-wt, germinal BRCA1/2-wild type triple negative tumors; gBRCA-mut, germinal BRCA1/2-mutant tumors.