FIGURE 4.

Schematic representation of crocetin's molecular mechanism of oxygen diffusion‐ enhancing action. (a). Diffusion of O₂ from erythrocytes through transition layer (plasma), out of vascular wall into the surrounding tissue; (b). Front‐view of ordered water structure surrounding the crocetin molecule (polar heads and hydrophobic interior); (c). Side‐view od ordered water structure surrounding crocetin molecule. Water molecules are shown in element color (ball‐and‐stick model); crocetin is shown in element color (capped stick) with non‐polar H atoms hidden for clarity