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. 2021 Apr 4;82(7):883–895. doi: 10.1002/ddr.21814

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© 2021 Wiley Periodicals LLC.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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SCHEME 2 — Synthesis of key intermediate 15 (route 1). ^aReagents and Conditions. a. Triethyl phosphite, 140 °C (Yield: 94%); b. NaOH, K₂CO₃, toluene/cyclohexane (Yield: 66%); c. AcOH, THF/H₂O (Yield: 59%); d. pTSA, 1,4‐dioxane (Yield: 67%)