REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse anti-NeuN; 1/400 dilution	Millipore	Cat#MAB377, RRID: AB_2298772
Mouse anti-GFAP (clone G-A-5); 1/500 dilution	Sigma	Cat#G6171, RRID: AB_1840893
Rabbit anti-Iba1; 1/500 dilution	Wako	Cat#019–19741, RRID: AB_839504
Rabbit anti-cleaved caspase3 (Asp175); 1/250 dilution	Cell Signaling Technology	Cat#9661S, RRID: AB_2341188
Goat biotinylated anti-rabbit IgG (H&L); 1/400 dilution	Vector Laboratories	Cat#BA-1000, RRID: AB_2313606
Goat biotinylated anti-mouse IgG (H&L); 1/400 dilution	Vector Laboratories	Cat#BA-9200, RRID: AB_2336171
Alexa Fluor® 488 Goat Anti-Rabbit IgG (H+L); 1/300 dilution	Thermo Fisher Scientific	Cat#A-11034, RRDI: AB_2576217
Alexa Fluor® 555 Goat Anti-Mouse IgG (H+L); 1/300 dilution	Thermo Fisher Scientific	Cat#A-21424,RRID: AB_141780
Chemicals, peptides, and recombinant proteins
PBS	Thermo Fisher Scientific	AAJ75889K8
Heparin sodium salt	Sigma-Aldrich	H4784
Procaine hydrochloride	Fluka	81666
16% Paraformaldehyde	Electron Microscopy Sciences	15710
DAB peroxidase substrate	Vector Laboratories	Cat#SK-4100, RRID: AB_2336382
Normal Goat Serum blocking solution	Vector laboratories	S-1000
Tissue-Tek O.C.T. Compound	Sakura	4583
Histoclear	National Diagnostics	HS-200
Absolute ethanol	Fisher Scientific	04-355-223
VECTASHIELD Mounting Medium	Vector Laboratories	H-1000
DAPI	Thermo Fisher Scientific	D1306
Cresyl Violet	Sigma-Aldrich	D5042
Acetic acid (glacial)	Sigma-Aldrich	1000631011
Sudan Black B	Sigma-Aldrich	199664-25G
Xylenes	Sigma-Aldrich	534056-4L
Harris Modified Method Hematoxylin Stains	Fisher Scientific	SH30-500D
Paraplast Plus	Leica	39602004
30% Hydrogen peroxide	Sigma-Aldrich	H1009
Citric acid (anhydrous)	Sigma-Aldrich	1370021000
Sodium citrate tribasic dihydrate	Sigma-Aldrich	C8532-1Kg
Critical commercial assays
In Situ Cell Death Detection Kit	Roche	11684795910
TUNEL dilution buffer	Sigma	11966006001
VECTASTAIN Elite ABC Kit	Vector Laboratories	Cat#PK-6100, RRID: AB_2336819
Experimental models: Organisms/strains
Mouse: EX-PS cDKO	Saura et al., 2004	N/A
Mouse: APP cTKO	Lee et al., 2020	N/A
Mouse: IN-PS cDKO	Kang and Shen, 2020	N/A
Software and algorithms
BioQuant image analysis software	BIOQUANT Life Science	RRID: SCR_016423
Other
Millex-GV Filter, 0.22 μm	Millipore	SLGV004SL
Olympus BX-51 microscope	Olympus	BX-51
Olympus BX-40 microscope	Olympus	BX-40
Olympus IX-51 microscope	Olympus	IX-51
Nikon Ci-L microscope	Nikon	Ci-L
Excelsior™ AS Tissue Processor	Thermo Fisher Scientific	A82300001
HistoCore Arcadia H - Heated Paraffin Embedding Station	Leica	14039357258
Tissue-Tek® Base Molds for Embedding Rings	EMS	62528-38
HistoCore Arcadia C - Cold Plate	Leica	14039380101
20-Slide Staining Dish Complete Set	EMS	71420-25
Rotary microtome	Leica	RM2125 RT
Cryostat	Leica	CM1950
Fisherbrand ColorFrost Plus Microscope Slides	Fisher Scientific	12-550-17
Fisherbrand Tissue Path MACROSETTE Processing/Embedding Cassettes	Fisher Scientific	15-182-706