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. 2021 Jun 28;11:707742. doi: 10.3389/fonc.2021.707742

Table 1.

Basic characteristics of included studies.

Study Country Patients (n) Sex (M/F) TNM stage (n) cut-off value with HR (P value) calculation method for cut-off value NOS
NLR MLR/LMR PLR
Wu (9) China 85 NR I/II/III/IV (21/13/47/6) 2.3 1.77 (0.016) NR NR median value of effect size 9
Gao (10) China 90 47/43 I/II/III/IV (54/11/23/2) 5 3.09 (0.027) NR NR refer to others 8
Zhang (11) China 145 68/77 I/II/III/IV (7/12/75/51) 1.94 NR 113.3 ROC curve 8
2.73 (0.001) 1.74 (0.001)
Beal (12) America 187 NR NR 5 NR NR refer to others 8
3.52 (0.02)
Zhang (13) China 316 215/101 I–II/III–IV (28/288) 2.61 NR NR ROC curve 8
1.65 (0.008)
Cui (14) China 159 NR I/II/III/IV (13/27/50/69) 4.39 0.30/NR 181 ROC curve 8
1.57 (0.01) 1.61 (0.006) 1.24 (0.23)
Tao (15) China 84 28/56 III/IV (35/49) 3.2 0.25/NR 117.7 ROC curve 9
2.348 (0.002) 2.42 (0.001) 1.859 (0.024)
Du (16) China 220 122/98 NR 5.1 NR/2.92 178 X‐tile software 7
1.38 (0.62) 0.69 (0.03) 0.75 (0.44)
Choi (17) South Korea 178 95/83 III/IV (39/139) 2 0.24/NR 108 refer to others 9
2.06 (0.001) 2.53 (0.001) 1.69 (0.019)
Deng (18) China 169 55/114 I/II/III/IV (16/37/76/40) 2.61 NR/2.66 145.3 ROC curve 8
3.30 (0.008) 1.55 (0.027) 1.221 (0.376)
Liu (19) China 90 NR I–II/III–IV (20/70) 4.33 NR NR mean value of effect size 7
3.84 (0.01)
Navarro (20) South Korea 197 83/114 II/III/IV (148/41/8) 2.4 NR/4 148 ROC curve 8
1.80 (0.44) 1.25 (0.739) 0.53 (0.432)
You (21) South Korea 173 87/86 III/IV/IV (1/8/164) 3 NR 190 refer to others 8
1.65 (0.017) 1.19 (0.405)
Mady (22) America 231 72/159 NR 5 NR NR refer to others 9
1.70 (0.003)

TNM, tumor/node/metastasis stages; HR, Hazard Ratio; NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; LMR, lymphocyte-to-monocyte ratio; PLR, platelet-to-lymphocyte ratio; NR, not reported; ROC, receiver operating characteristic; NOS, Newcastle–Ottawa Scale.