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. 2021 Jun 28;12:653349. doi: 10.3389/fphys.2021.653349

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Copyright © 2021 Wei, Guo, Pan, Li, Cui, Yan, Fan, Deng, Hu, Chang, He, Yan, Sun, Wang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of T₈₉ on survival rate, MBF, and heart function in rats exposed to ISO. (A) The survival curve of each group. (B) Representative color images of MBF in different groups acquired by Laser-Doppler Perfusion Imager. b1: Sham; b2: Sham + T₈₉ 167.4; b3: ISO; b4: ISO + T₈₉ 111.6; b5: ISO + T₈₉ 167.4. (C) Quantitative evaluation of MBF, n = 12. (D) Presented are the value of HR (d1), LVSP (d2), +dp/dt max (d3), LVDP (d4), LVEDP (d5), and -dp/dt max (d6) in various groups, n = 6. Data are presented as mean ± SE. *P < 0.05 vs. Sham group, ^#P < 0.05 vs. ISO group.