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. 2021 Jun 28;12:653349. doi: 10.3389/fphys.2021.653349

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Copyright © 2021 Wei, Guo, Pan, Li, Cui, Yan, Fan, Deng, Hu, Chang, He, Yan, Sun, Wang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of T₈₉ on ISO-induced alteration in metabolism and mitochondrial function. (A,B) Representative Western blotting bands and quantitative analysis of Eno1, Mcee, Bdh1, Ces1c, and Cbr4 in various groups. n = 4. (C,D) The content of pyruvic acid (C) and 3-HYA (D) in left ventricles in different groups. n = 6. (E,F) Representative Western blotting bands and quantitative analysis of ND2, Cox6a, Cox17, and ATP5j in various groups. n = 4. (G) The activity of complex I, IV, and V in left ventricles. n = 6. (H,I) The level of TBARS (H), and the ratio of ATP/AMP (I) in left ventricles. n = 6. *P < 0.05 vs. Sham group, ^#P < 0.05 vs. ISO group.