TABLE 2.

The altered proteins enriched in lipid metabolism pathways evoked by ISO.

Lipid metabolism pathways	Altered proteins (ISO vs. Sham)	Up or down
Triglycerides metabolism	Agpat3, Ppt1, Lclat1, Ces1c	Up
Arachidonic acid metabolism	Ptgis	Up
Short-chain fatty acid catabolism	Mcee	Up
Synthesis and degradation of ketone bodies	Bdh1	Up
Long chain omega-hydroxy fatty acids oxidation	Adh4	Down
Lipid digestion, mobilization and transport	Fabp3, Apoc2, Lp1, Gpcpd1	Down
Fatty acyl-CoA biosynthesis	Acsf2, Acsl1, Tecr, Cbr4, Gcdh	Down
Mitochondrial fatty acid β-oxidation	Acaa2, Acat1, Decr1, Eci1, Echs1, Gcdh, Hadh, Hadhb	Down

ISO-induced altered proteins enriched in lipid metabolism pathways. Acaa2, 3-ketoacyl-CoA thiolase; Acat1, acetyl-CoA acetyltransferase; Acsf2, acyl-CoA synthetase family member 2; Acsl1, long-chain-fatty-acid–CoA ligase 1; Adh5, alcohol dehydrogenase class-3; Agpat3, 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Apoc2, apolipoprotein C-II precursor; Bdh1, D-beta-hydroxybutyrate dehydrogenase; Cbr4, carbonyl reductase family member 4; Ces1c, carboxylesterase 1C; Decr1, 2,4-dienoyl-CoA reductase; Echs1, enoyl-CoA hydratase; Eci1, enoyl-CoA delta isomerase 1; Fabp3, fatty acid-binding protein; Gcdh, glutaryl-CoA dehydrogenase; Gpcpd1, glycerophosphocholine phosphodiesterase; Hadh, trifunctional enzyme subunit beta; Hadhb, trifunctional enzyme subunit beta; Lclat1, lysocardiolipin acyltransferase 1; Lp1, lipoprotein lipase precursor; Mcee, methylmalonyl-CoA epimerase; Ppt1, palmitoyl-protein thioesterase 1 precursor; Ptgis, prostacyclin synthase precursor; Tecr, very-long-chain enoyl-CoA reductase.