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. 2021 Jun 28;15:668286. doi: 10.3389/fncel.2021.668286

FIGURE 3.

FIGURE 3

AM251 ameliorates anxiety and depressive-like behavior in irradiated mice. EPM: Short-term AM251 treatment reduced anxiety-like-behavior in mice 6 weeks following irradiation evidenced by the significant increased time spent in open arms (A1,A2). However, benefits derived from this same short-term treatment did not persist 12 weeks after irradiation (B1,B2). At similar protracted postirradiation times, long-term AM251 treatments were found to significantly reduce anxiety-like behavior (C1,C2). Delayed AM251 treatment was not effective at resolving radiation-induced anxiety-like behavior 13 weeks after irradiation (D1,D2). FST: Short-term AM251 treatment reduced significantly depressive-like behavior in irradiated mice at 6 weeks after irradiation (E1) but not at 12 weeks postirradiation (F1). Long-term treatments with AM251 improved were found to reduce depressive-like behavior 13 weeks following irradiation (G1) but not when a single treatment was delayed (H1). Data presented as means ± SEM, N = 8–12. P-values derived from two-way ANOVA followed by Bonferroni correction for multiple comparisons. *P < 0.05; **P < 0.01; and ***P < 0.001.