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. 2021 Jun 28;11:662135. doi: 10.3389/fonc.2021.662135

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Copyright © 2021 Özkan, Stolley, Cressman, McMillin, DeMorrow, Yankeelov and Rylander

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oxygen depletion modeling in ECM and culture media. (A) Computational domain of the problem in 2D axisymmetric configuration. (B) Temporal average oxygen concentration in collagen hydrogels. Oxygen concentration distribution reaches steady state less than one hour after cell seeding. No marginal variation was observed in oxygen concentrations between native and cirrhotic hydrogels. (C) 3D contour of oxygen concentration across the collagen hydrogel and culture media after system reaches steady state.