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. 2021 Jun 28;11:662135. doi: 10.3389/fonc.2021.662135

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Copyright © 2021 Özkan, Stolley, Cressman, McMillin, DeMorrow, Yankeelov and Rylander

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combined doxorubicin and sorafenib treatment efficacy of HCC cell lines under the influence of hypoxia and cirrhosis. HCC cell types show sensitivity to combined sorafenib and doxorubicin treatment for 24 hours. Cells cultured in 3D normal and cirrhotic hydrogels in hypoxic and normoxic conditions. Cell viability was analyzed and plotted as a percentage of the untreated control. A combination of doxorubicin with sorafenib improves treatment efficacy. The influence of cirrhosis decreased HCC cell death.