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Regulation of CYP3A4 is responsible for drug metabolization by HCC cell lines in response to hypoxic and cirrhotic conditions. Presence of cirrhosis and hypoxia altered CYP3A4 activity differently between HCC cell lines. Data represented as mean ± standard deviation. * denotes significance for cirrhotic and normal 3D samples compared to the 2D monolayer. *p < 0.05, **p < 0.01.
