Table 3.
Subgroup analyses
| Time to vasopressor discontinuation, hours | |||||
|---|---|---|---|---|---|
| Effect modifier | Midodrine | Placebo | Difference (95% CI) | IRR (95% CI) | P value |
| Epidural analgesia (P for interaction = 0.030) | |||||
| Epidural analgesia (n = 31) | 14.8 (5.5–21.5) | 33.1 (20.4–47.0) | −18.4 (−33.5 to −3.3) | 0.53 (0.28 to 0.99) | 0.045 |
| No epidural analgesia (n = 101) | 31.7 (14.2–71.5) | 22.0 (9.8–36.0) | 9.7 (−6.3 to 25.7) | 1.48 (0.92 to 2.35) | 0.103 |
| Indication for ICU admission (P for interaction = 0.171 and 0.066) a | |||||
| Postoperative/surgical (n = 87) | 22.2 (12.5–47.0) | 23.8 (9.8–51.0) | −1.6 (−13.1 to 9.9) | — b | — b |
| Sepsis (n = 26) | 40.0 (7.0–108.2) | 24.0 (17.0–39.3) | 16.0 (−65.7 to 97.7) | — b | — b |
| Medical/other reason (n = 19) | 24.1 (10.0–53.5) | 15.0 (1.9–23.5) | 9.1 (−18.1 to 36.2) | — b | — b |
Data are expressed as median (interquartile range (25th-75th percentile), values separated by comma). IRR: incidence rate ratio.
a
P values for interaction terms are reported for sepsis and medical/other reason, respectively. Postoperative/surgical indication was considered as reference group.
b
Only descriptive data are reported; no subgroup analyses were performed in the absence of significant interaction.