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. 2021 Jul 6;46(2):181. doi: 10.3892/or.2021.8132

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Overexpression of MALAT1 promotes the progression of MCF-7 cells, while silencing of MALAT1 inhibits the progression of MDA-MB-231 cells. (A) The growth curves based on CCK-8 assay data of MCF-7-overexpressed MALAT1 cells were compared with those of control cells. (B) Immunofluorescence staining of MCF-7 cells. Red fluorescence, MALAT1; DAPI was used to stain nuclear DNA. (C) The migration abilities of MCF-7-overexpressed MALAT1 and control cells were compared based on wound healing assays. (D) The migration and invasion abilities of transfected MCF-7 cells were determined by Transwell assays. (E) Growth curves of MDA-MB-231 siMALAT1 cells based on CCK-8 assay data were compared with those of control cells. (F) Immunofluorescence staining of MDA-MB-231 siMALAT1 cells. Red fluorescence, siMALAT1; DAPI was used to stain nuclear DNA. (G) The migration abilities of MDA-MB-231 siMALAT1 cells and control cells were compared based on wound healing assays. (H) The migration and invasion abilities of transfected MDA-MB-231 siMALAT1 cells were determined by Transwell assays. *P<0.05. MALAT1, metastasis-associated lung adenocarcinoma transcript 1; CCK-8, Cell Counting Kit-8; si, small interfering.