Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 6;46(2):181. doi: 10.3892/or.2021.8132

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 3. — MALAT1 interacts with miR-26a/26b to regulate ST8SIA4 expression in MCF-7 and MDA-MB-231 cells. (A) There was a negative relationship between the expression of MALAT1 and miR-26a or miR-26b expression (P<0.0001). (B) The expression of miR-26a and miR-26b was examined by RT-qPCR in the MCF-7 cells. (C) The expression of miR-26a and miR-26b was examined by RT-qPCR in the MDA-MB-231 cells. (D) ST8SIA4 protein levels were significantly increased with upregulation of MALAT1 in MCF-7 cells and decreased with knockdown of MALAT1 in MDA-MB-231 cells as revealed by western blot analysis. *P<0.05. MALAT1, metastasis-associated lung adenocarcinoma transcript 1; miR, microRNA; ST8SIA4, α-2,8-sialyltransferase; RT-qPCR, reverse transcription-quantitative PCR; si, small interfering; SCR, scrambled.