Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 7;46(2):184. doi: 10.3892/or.2021.8135

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 3. — Inhibitory effect of TRF2 on damaged telomere C-NHEJ. (A) The damaged shortened telomere ends bind to the Ku70/80 protein, and via mutual affinity of the Ku70 5α domains, a Ku70/80 heterotetramer is formed, leading to chromosome end-to-end fusion. (B) TRF2 directly binds to the 5α domain of Ku70 to prevent the formation of the Ku70/80 heterotetramers and inhibits the recruitment to the telomere ends of DNA-PKcs, Lig4, XRCC4, XLF, making the ends unable to be effectively connected. TRF2, telomeric repeat-binding factor 2; C-NHEJ, canonical non-homologous end joining; DNA-PKcs, DNA-dependent protein kinase catalytic subunits; Lig4, DNA ligase IV; XLF, XRCC4-like factor.