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. 2021 Jun 28;12:595150. doi: 10.3389/fimmu.2021.595150

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Copyright © 2021 Hammoudeh, Hammoudeh, Bhamidimarri, Al Safar, Mahboub, Künstner, Busch, Halwani, Hamid, Rahmani and Hamoudi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Count of differentially expressed immune response genes from the immune response gene ontology set (GO:0006955) in SARS-CoV-2 infected lung, liver, kidney, and heart tissues. Venn diagram representation of the overlap of significantly (B) upregulated and (C) downregulated immune response genes amongst the four types of infected tissues. Functional clustering and pathway analysis of the commonly (D) upregulated and (E) downregulated genes across lung, liver, kidney, and heart tissues in response to SARS-CoV-2 infection.