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. 2021 Jun 28;12:595150. doi: 10.3389/fimmu.2021.595150

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Copyright © 2021 Hammoudeh, Hammoudeh, Bhamidimarri, Al Safar, Mahboub, Künstner, Busch, Halwani, Hamid, Rahmani and Hamoudi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Top 30 upregulated immune response genes in lung, liver, kidney, and heart tissues in response to SARS-CoV-2 infection; F.C.: fold change; light red represents commonly upregulated genes within the top 20 genes across the 4 types of tissues. (B) Venn diagram representation of the overlap between the top 20 upregulated immune response genes in each tissue, enlisted in (A). (C, D) Top Immune response genes uniquely upregulated in lung, liver, kidney, and heart tissues in response to SARS-CoV-2 infection. * represents p-value < 0.05; ** represents p-value < 0.01 analyzed using T-test statistical analysis.