Figure 1.

Classification by height adjusted total kidney volume at baseline (htTKV0) and age at htTKV0 predicts the change in estimated glomerular filtration rate (eGFR) over time in class 1 patients. (A) Subclassification of patients with class 1 autosomal dominant polycystic kidney disease at baseline based on height adjusted total kidney volume (htTKV) limits for their age. Limits are defined based on estimated kidney growth rates of 1.5%, 3.0%, 4.5%, and 6.0%. (B) Slopes for men based on the longitudinal mixed-effects model for future eGFR using classification as baseline predictor. The average eGFR at baseline (75 mL/min/1.73 m²) and the average age at baseline (44 years) for all class 1 patients were used for the model. Estimated slopes (mL/ min/1.73 m² per year) by subclass (A–E) are –0.23, –1.33, –2.63, –3.48, and –4.78, respectively, for men and 0.03, –1.13, –2.43, –3.29, and –4.58, respectively, for women (not plotted). Adapted from Irazabal et al., with permission of American Society of Nephrology [49]. a Values for normal slope were obtained from a population of healthy kidney donors.