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Possible mechanisms of high dietary protein intake on kidney health. High protein diet leads to the dilation of the afferent arteriole and increased glomerular filtration rate, which may lead to damage to kidney structure over time due to glomerular hyperfiltration. RAAS, renin-angiotensin-aldosterone system; TGF-β, transforming growth factor-beta; RAGE, receptor for advanced glycation end products; DKD, diabetic kidney disease.
