Table 3.
Comparison of subjects with advanced colorectal neoplasia (ACRN) according to detection models
| Characteristic | ACRNs detected both by LR and DNN (n = 157) | ACRNs detected only by LR model (n = 7) | ACRNs detected only by DNN model (n = 8) | p value |
|---|---|---|---|---|
| Age, yr | 51.5 ± 10.4 | 32.4 ± 4.8 | 43.4 ± 3.2 | 0.001 |
| Male sex | 138 (87.34) | 7 (100.0) | 2 (25.0) | < 0.001 |
| Current smoker | 65 (41.1) | 2 (28.6) | 3 (37.5) | 0.791 |
| Alcohol consumption, time/wk | 2 (1–3) | 1 (0–2) | 1.5 (1–2.5) | 0.214 |
| Regular exercise ≥ 4 times/wk | 88 (55.7) | 4 (57.4) | 3 (37.5) | 0.597 |
| Family history of CRC | 9 (5.7) | 0 (0) | 0 (0) | 0.637 |
| Hypertension | 35 (22.2) | 0 (0) | 2 (25.0) | 0.364 |
| Diabetes | 18 (11.4) | 0 (0) | 0 (0) | 0.385 |
| BMI, kg/m2 | 24.6 ± 2.8 | 25.4 ± 5.1 | 22.1 ± 2.1 | 0.031 |
| Waist circumference, cm | 86.7 ± 7.4 | 86.4 ± 11.2 | 78.1 ± 4.8 | 0.100 |
| Systolic BP, mmHg | 113.7 ± 12.5 | 93.0 ± 5.2 | 108.5 ± 13.8 | 0.106 |
| Diastolic BP, mmHg | 72.6 ± 9.6 | 60.8 ± 5.0 | 70.1 ± 10.4 | 0.241 |
| Glucose, mg/dL | 99.2 ± 16.8 | 91.3 ± 11.4 | 86.8 ± 8.0 | 0.053 |
| HbA1c, % | 5.9 ± 0.6 | 5.5 ± 0.1 | 5.5 ± 0.2 | 0.065 |
| Total cholesterol, mg/dL | 209.8 ± 34.6 | 197.9 ± 28.8 | 172.8 ± 26.6 | 0.593 |
| HDL-C, mg/dL | 50.9 ± 12.3 | 50.6 ± 11.4 | 60.3 ± 16.4 | 0.510 |
| Triglyceride, mg/dL | 125 (93–191) | 100 (67–152) | 67 (52–92.5) | 0.004 |
| LDL-C, mg/dL | 134.7 ± 32.8 | 133.0 ± 27.9 | 100.0 ± 25.8 | 0.645 |
| Insulin, μU/mL | 5.5 (3.3–7.8) | 7.3 (2.5–10.6) | 3.5 (1.5–3.9) | 0.088 |
| hsCRP, mg/L | 0.1 (0.0–0.1) | 0.0 (0.0–0.1) | 0.1 (0.0–0.1) | 0.031 |
| WBC, × 103/mm3 | 6.9 ± 2.0 | 5.4 ± 0.8 | 7.4 ± 1.6 | 0.046 |
| RBC, × 106/mm3 | 4.9 ± 0.4 | 5.1 ± 0.2 | 4.4 ± 0.3 | 0.110 |
| Hemoglobin, g/dL | 15.4 ± 1.3 | 15.8 ± 0.6 | 13.9 ± 1.3 | 0.134 |
| Hematocrit, % | 45.2 ± 3.4 | 45.7 ± 2.3 | 41.3 ± 2.8 | 0.424 |
| Platelet, × 103/mm3 | 252.9 ± 58.1 | 223.9 ± 54.3 | 270.4 ± 38.8 | 0.433 |
| Ferritin, ng/mL | 154.2 (98.6–216.3) | 203.8 (140.9–326.8) | 81.9 (34.9–116.2) | 0.034 |
| CEA, ng/mL | 1.8 (1.2–2.5) | 1.2 (1.1–1.5) | 1.7 (1.1–2.8) | 0.295 |
Values are presented as mean ± SD, number (%), or median (interquartile range).
LR, logistic regression; DNN, deep neural network; BMI, body mass index; BP, blood pressure; HbA1c, hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; WBC, white blood cell; RBC, red blood cell; CEA, carcinoembryonic antigen.