Table 1.

Basic parameters in each group

Variable	VH	Tac	Tac + CoQ10-L	Tac + CoQ10-W
Body weight, g	67 ± 3	48 ± 5a	62 ± 1b	62 ± 2b
Water intake, mL/day	16 ± 2	23 ± 1a	18 ± 1b	20 ± 2b
Urine volume, mL/day	30 ± 2	49 ± 6a	35 ± 1b	39 ± 4b
Scr, mg/dL	0.31 ± 0.03	0.43 ± 0.4a	0.37 ± 0.03a	0.30 ± 0.02 b,c
Tac conc., ng/mL	-	9 ± 4	9 ± 2	9 ± 3

Values are presented as mean ± standard error (n = 9).

VH, vehicle; Tac, tacrolimus; CoQ10-L, lipid-soluble coenzyme q10; CoQ10-W, water-soluble CoQ10; Scr, serum creatinine; Tac conc., trough concentration of Tac.

^ap < 0.05 vs. VH.

^bp < 0.05 vs. Tac.

^cp < 0.05 vs. Tac + CoQ₁₀-L.