. 2020 Sep 3;115(1):28–40. doi: 10.1111/mmi.14589

TABLE 2.

ES24 structure‐activity analysis

Compound	MIC E. coli ^b	LD₅₀ HEK293 ^b	Interference NG‐WALP‐F‐TolR insertion ^c
NFT	25	80	No
Furagin	3	>80	No
ES24	25	80	Yes
ES24‐D1	>100	>80	No
ES24‐D2	50	80	No

^{^a}

Structural differences between compounds are highlighted with different colors.

^{^b}

The MIC value and median lethal dose (LD₅₀) are given in µM. Inhibitory curves can be found in the supporting information (Figure S5).

^{^c}

Compounds were assayed for their ability to interfere with membrane insertion of NG‐WALP‐F and NG‐WALP‐F‐TolR, as described in the legend of Figure 2. Representative microscopy pictures are shown in the supporting information (Figure S6).