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. 2021 Jun 9;21(7):4141–4150. doi: 10.1021/acs.cgd.1c00418

Table 1. Solubility Data for Each Coformer in Water, MeOH, MeCN, EtOAc, and MEK.

compound name water (mg/mL) MeOH (mg/mL) MeCN (mg/mL) EtOAc (mg/mL)
benzoic acid <1.0 306.4 81.5 175.0
trans-1,2-bis(4-pyridyl)ethylene <1.0 289.0 <1.0 <1.0
4,4′-bipyridine 1.8 456.7 84.1 134.6
glutaric acid 570.0 458.0 99.5 602.2
1,2-bis(4-pyridyl)ethane <1.0 426.6 115.7 67.1
4,4′-biphenol <1.0 57.1 13.3 56.1
tetramethylpyrazine <1.0 <1.0 <1.0 <1.0
isophthalic acid <1.0 10.8 2.0 3.4
trimesic acid <1.0 <1.0 <1.0 1.8
hydroquinone 72.9 269.6 100.8 165.1
naproxen <1.0 53.6 36.7 50.5
benzoquinone 1.8 4.8 15.2 57.7
carbamazepine <1.0 63.4 43.5 12.7
4-aminobenzoic acid 2.7 146.9 57.9 75.5
oxalic acid 85.3 190.3 110.6 96.8
aspirin 2.0 221.8 63.3 25.4
1-naphthol 2.7 197.0 71.3 61.2
terephthalaldehyde <1.0 221.5 76.2 79.7
saccharin 2.9 36.4 28.2 30.2
nicotinamide 419.1 180.2 21.2 10.8
2,7-dihydroxynaphthalene 4.5 379 76.2 79.7
resorcinol 566.5 544.4 525.8 443.5
2,6-pyridinecarboxylic acid 4.0 22.9 <1.0 <1.0