Table 2. SAR Studies around the C-5 Isoxazole Position^a.

^aGlide scores, TR-FRET IC₅₀ values (μM) from the coactivator recruitment and AlexaFluor-MRL-871 displacement assays, ΔT_m values (°C) from TSA, and fold decrease in IL-17a expression levels relative to DMSO (RT-PCR) are shown. Abbreviations: n.d., not determined. TR-FRET and TSA data are recorded in triplicate; values are representative of ≥3 repeated experiments. RT-PCR data are recorded in triplicate; values are representative of ≥2 repeated experiments.