Table 4. ADME Properties for Compounds 1, 2, 3, 6, 9, 10, and 11.

			microsomal stability
compound	kinetic solubility (μM)	PAMPA (% flux)	phase 1 (Clint, μL/min/mg)	glucuronidation in vitro (% remaining)	plasma stability (% remaining)	plasma protein binding (% bound)
1	423	29.7	0.4	37.7	95.5	99.7
2	460	36.1	31.2	73.0	79.1	99.9
3	436	40.9	57.8	30.7	74.2	99.7
6	392	40.3	69.0	58.3	59.5	99.9
9	445	37.3	77.0	54.6	97.1	99.8
10	421	50.5	68.0	68.9	89.5	99.3
11	476	23.0	8.8	39.1	100	98.8