Table 2.
Expanded list of novel antigens of ETEC.
| Antigen/Epitope | Description/Role in Pathogenesis |
|---|---|
| EtpA | Secreted adhesin, intestinal colonization, toxin delivery |
| EatA and Ag43 | Mucin degrading serine protease, toxin delivery |
| EaeH | Outer membrane adhesin, toxin delivery |
| ECP | E. coli common pilus, role in pathogenesis not known |
| Flagellin | Flagellar H subunit involved in motility, toxin delivery |
| Type 1 Fimbriae | Involved in toxin delivery |
| YghJ Metalloprotease1 | T2SS, mucin degrading, toxin release |
| MipA2 | Remodelling peptidoglycan, role in pathogenesis not known |
| Skp2 | Molecular chaperon, OMP, role in pathogenesis not known |
| ETEC_24792 | OMP, LCFA transport |
| EspB | Effector protein; part of the Type 3 secretory system in EPEC |
| LPS (O) | Sero-determinant, role in pathogenesis is not clear |
EatA and EtpA are plasmid encoded, all other putative novel antigens are chromosomally encoded.
1
YjhJ also may be designated as SslE and can be expressed as a cell surface associated and secreted lipoprotein with mucinase activity in some ETEC, typical EPEC and extraintestinal E. coli, like uropathogenic (UPEC) and neonatal sepsis associated (NSEC) E. coli strains.
2
Conserved epitope also present in commensal E. coli. Impact of using subunit vaccines consisting of proteins encoded by commensal bacteria are not known. However, vaccination with these proteins did not significantly alter host intestinal microbiome in animals.