Figure 3.

Pathway representing pancreatic cancer (PaCa) progression from normal pancreas cell to invasive stage of cancer. ECM molecules initiate multiple signaling pathways by interacting with integrin complexes. The growth factor receptors MET and EGFR/HER2 activation in initial stages of PaCa, activates signaling cascades, which lead to expression of anti-apoptotic, proliferative, and cell survival genes. Figure represent the information related to gene identified in number of datasets in WGCNA and differential gene expression (DE) analysis. Color filled in entities show the dataset number for WGCNA. Color of stars represent number of DE datasets.